A Brief & Comparative Study on the Antimicrobial Evaluation of 3,5 Di- Substituted Pyrazoles with the Bromo-Substituted Pyrazoles.
Keywords:
Pyrazoles, Phenyl hydrazine, 1,3-diketone, antibacterial activity, anti- fungal activity, microorganismsAbstract
The new substituted pyrazoles were prepared from the 2 hydroxy-3,5- dichloro acetophenone in ethanol and
aromatic aldehyde as the starting materials through 1,3-diketones as the intermediates. The intermediates on reaction with the
hydrazines in the alkaline media, finally gets converted into corresponding pyrazoles. The synthesized compounds were
characterized by their physical properties, IR and NMR spectroscopic studies. The antimicrobial activity of synthesized
pyrazoles was assessed by agar cup method and filter paper disc method. Purity of these heterocycles was checked by the
TLC. These compounds were tested for the antimicrobial activity against pathogenic bacteria, i.e., Staphylococeus aureus,
Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella flexueri, Escherichia coli & Pseudomonas aerugivosa &
MIC are found to have remarkable activity. In maximum cases, pyrazole having bromo substitution on styryl ring was found
to be more efficient than remaining against some micro-organisms.